Dosing Guided by Symptoms1

LUCEMYRA® should be taken orally, four times per day, for the expected duration of withdrawal symptoms

Usual LUCEMYRA starting dosage:

Three 0.18 mg tablets (0.54 mg) taken orally 4 times daily during peak withdrawal symptoms (generally, this is the first 5 to 7 days after the last use of an opioid).

Dosing for LUCEMYRA should be guided by symptoms and side effects

A lower dose can be considered for patients with less severe symptoms or patients who present with additional concerns such as advanced age, low weight, or poor tolerability.

There should be 5 to 6 hours between each dose

LUCEMYRA can be taken with or without food

The total daily dosage of LUCEMYRA should not exceed 2.88 mg (16 tablets) and no single dose should exceed 0.72 mg (4 tablets)

LUCEMYRA treatment may be continued for up to 14 days as guided by symptoms

Examples of dosing guided by symptoms

LUCEMYRA was studied in phase I drug interaction studies with commonly used therapies for Opioid Use Disorder: buprenorphine, methadone, and oral naltrexone

  • LUCEMYRA and methadone both prolong the QTinterval. ECG monitoring is recommended in patients receiving methadone and LUCEMYRA
  • It is possible that oral naltrexone efficacy maybe reduced if used concomitantly within 2 hours of LUCEMYRA. This interaction is not expected if naltrexone is administered by non-oral routes

There are no contradictions associated with LUCEMYRA

  1. LUCEMYRA® (lofexidine) [Prescribing Information]. USWM, LLC; 2020



The LUminate Support Program provides your patients with a variety of tools and resources to help them get through opioid withdrawal


Read about a 5-Day treatment study where LUCEMYRA significantly reduced the severity of withdrawal symptoms


Details and examples for the best practices while taking LUCEMYRA